Deregulated transcription is causal for a large fraction of human diseases such as cancer and autoimmune disorders. Our interest is to elucidate how regulation of specific transcripts relevant to pathogenesis is brought about mechanistically.
We focus on regulation of inducible gene expression, more precisely on
- deacetylase-independent functions of NCOR/SMRT complexes
- analysing how soluble mediators modulate the NFκB response in macrophages, e.g. for immune evasion in ovarian carcinoma and other tumour entities.
Last modified 15.10.2020