We study how transcription is regulated in disease as well as its modulation by druggable factors, in particular by nuclear receptors.
We are investigating the epigenetic and gene-regulatory functions of protein arginine methyltransferases (PRMTs) in mammalian cells.
We maintain a large scale fly culture and are combining biochemical, genetic and molecular biology approaches to investigate conserved tumour suppressor complexes and chromatin regulators.
We aim to better understand the regulatory mechanisms of the polycomb repressive complex 2 (PRC2) in a physiological and pathophysiological context. In particular we want to better understand the role of PRC2-associated factors in stem cell biology and cancer.
We wish to understand the chromatin-based mechanisms which control the identity and fate of mammalian cells.
Our research interest is molecular oncology with a focus on human ovarian cancer. We are particularly interested in intercellular signaling and molecular interactions within the tumor microenvironment, the transcriptional networks controlled by these interactions and their impact on tumor progression and therapy resistance --> OvaRA.
|Suske Lab (retired)|
Our general research interest is mammalian gene regulation. In particular, we are focusing on the biological and molecular functions exerted by members of the Sp family of transcription factors.