IMT

IMT - Adhikary Lab - Publications

Till Adhikary

Publications


Link to Google Scholar Profile

Legrand, N., Bretscher, C. L., Zielke, S., Wilke, B., Daude, M., Fritz, B., Diederich, W. E., and Adhikary, T. (2019). PPARβ/δ recruits NCOR and regulates transcription reinitiation of ANGPTL4. Nucleic Acids Res.,
doi.org/10.1093/nar/gkz685  (free download)

Luu, M., Pautz, S., Kohl, V., Romero, R., Lucas, S., Hofmann, J., Raifer, R., Vachharajani, N., Campos Carrascosa, L., Lamp, B., Nist, A., Stiewe, T., Shaul, Y., Adhikary, T., Zaiss, M. M., Lauth, M., Steinhoff, U., and Visekruna, A. (2019). The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes. Nat Commun.,
doi.org/10.1038/s41467-019-08711-2  (free download)

Luu, M., Weigand, K., Wedi, F., Breidenbend, C., Leister, H., Pautz, S., Adhikary, T., and Visekruna, A. (2018). Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate. Scientific Reports,
doi.org/10.1038/s41598-018-32860-x  (free download)

Weber, A., Schwarz, S. C., Tost, J., Trümbach, D., Winter, P., Busato, F., Tacik, P., Windhorst, A. C., Fagny, M., Arzberger, T., McLean, C., van Swieten, J. C., Schwarz, J., Vogt Weisenhorn, D., Wurst, W., Adhikary, T., Dickson, D. W., Höglinger, G. U., and Müller, U. (2018). Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1. Nat Commun.,
doi.org/10.1038/s41467-018-05325-y  (free download)

Unger, A., Finkernagel, F., Hoffmann, N., Neuhaus, F., Joos, B., Nist, A., Stiewe, T., Visekruna, A., Wagner, U., Reinartz, S., Müller-Brüsselbach, S., Müller, R., and Adhikary, T. (2018). Chromatin Binding of c-REL and p65 Is Not Limiting for Macrophage IL12B Transcription During Immediate Suppression by Ovarian Carcinoma Ascites. Front. Immunol.,
dx.doi.org/10.3389/fimmu.2018.01425  (free download)

Worzfeld, T., Finkernagel, F., Reinartz, S., Konzer, K., Adhikary, T., Nist, A., Stiewe, T., Wagner, U., Looso, M., Graumann, J. and Müller, R. (2018). Proteotranscriptomics reveal signaling networks in the ovarian cancer microenvironment. Mol. Cell. Proteomics,
dx.doi.org/10.1074/mcp.RA117.000400  (free download)

Adhikary, T., Wortmann, A., Finkernagel, F., Lieber, S., Nist, A., Stiewe, T., Wagner, U., Müller-Brüsselbach, S., Reinartz, S., and Müller, R. (2017).  Interferon signaling in ascites-associated macrophages is linked to a favorable clinical outcome in a subgroup of ovarian carcinoma patients. BMC Genomics,
dx.doi.org/10.1186/s12864-017-3630-9  (free download)

Worzfeld, T., Pogge von Strandmann, E.,  Huber, M., Adhikary, T., Reinartz, S., Wagner, U. and Müller, R. (2017).  The unique molecular and cellular microenvironment of ovarian cancer. Front. Oncol.
doi.org/10.3389/fonc.2017.00024 (free download)

Klingler, C., Zhao, X., Adhikary, T., Li, J., Xu, G., Häring, H.-U., Schleicher, E., Lehmann, R., Weigert, C. (2016).  Lysophosphatidylcholines activate PPARδ and protect human skeletal muscle cells from lipotoxicity. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids 1861(12)A, 1980–1992
doi.org/10.1016/j.bbalip.2016.09.020 

Finkernagel, F., Reinartz, S., Lieber, S., Adhikary, T., Wortmann, A., Hoffman, N., Bieringer, T., Nist, A., Stiewe, T., Jansen, J.M., Wagner, U., Müller-Brüsselbach, S. and Müller, R. (2016). The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization. Oncotarget. 17, 75339-75352.
doi.org/10.18632/oncotarget.12180   (free download)

Reinartz, S., Finkernagel, F., Adhikary, T., Rohnalter, V., Schumann, T., Schober, Y., Nockher, A.W., Nist, A., Stiewe, T., Jansen, J.M., Wagner, U., Müller-Brüsselbach, S. and Müller, R. (2016). A transcriptome-based global map of signaling pathways in the ovarian cancer microenvironment associated with clinical outcome. Genome Biol. 17: 108.
doi.org/10.1186/s13059-016-0956-6    (free download)

Toth, P.M., Lieber, S., Scheer, F.M., Schumann, T., Schober, Y., Nockher, W.A., Adhikary, T., Müller-Brüsselbach, S., Müller, R., Diederich, W.E. (2016). Design and synthesis of highly active PPARβ/δ inverse agonists with prolonged cellular activity. ChemMedChem 11, 488-496.
doi.org/10.1002/cmdc.201500594

Rohnalter, V., Roth, K., Finkernagel, F., Adhikary, T., Obert, J., Dorzweiler, K., Bensberg, M., Müller-Brüsselbach, S. and Müller, R. (2015). A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype. Oncotarget 6, 40005-40025.
doi.org/10.18632/oncotarget.5552  (free download)

Adhikary, T., Wortmann, A., Schumann, T., Finkernagel, F., Lieber, S., Roth, K., Toth, P.M., Diederich, W.E., Nist, A., Stiewe, T., Kleinesudeik, L., Reinartz, S., Müller-Brüsselbach, S. and Müller, R. (2015). The transcriptional PPARβ/δ network in human macrophages defines a unique agonist-induced activation state. Nucleic Acids Res. 43, 5033-5051.
doi.org/10.1093/nar/gkv331  (free download)

Schumann, T., Adhikary, T., Wortmann, A., Finkernagel, F., Lieber, S., Schnitzer, E., Legrand, N., Schober, Y, Nockher, A. W., Toth, P.M., Diederich, W.E., Nist, A., Stiewe, T., Wagner, U., Reinartz, S., Müller-Brüsselbach, S. and Müller, R. (2015). Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment. Oncotarget 6, 13416-13433.
doi.org/10.18632/oncotarget.3826  (free download)

Adhikary, T., and Müller, R. (2013). In Vivo Studies of PPAR-Chromatin Interactions: Chromatin Immunoprecipitation for Single-Locus and Genomewide Analyses. Peroxisome Proliferator-Activated Receptors (PPARs) Methods and Protocols 175-185.
doi.org/10.1007/978-1-62703-155-4_12 

Adhikary, T., Brandt, D.T., Kaddatz, K., Stockert, J., Finkernagel, F., Naruhn, S., Meissner, W., Obert, J., Lieber, S., Scharfe, M., Jarek, M., Toth, P.M., Scheer, F., Diederich, W.E., Reinartz, S., Grosse, R., Müller-Brüsselbach, S. and Müller, R. (2013). Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion. Oncogene 32, 5241-5252.
doi.org/10.1038/onc.2012.549  (free download)

Lieber, S., Scheer, F., Meissner, W., Naruhn, S., Adhikary, T., Müller-Brüsselbach, S., Diederich, W. and Müller, R. (2012). (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl} acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties. J. Med. Chem. 55, 2858-2868.

Naruhn, S., Toth, P.M., Adhikary, T., Kaddatz, K., Pape, V., Dörr, S., Klebe, G., Müller-Brüsselbach, S., Diederich, W. and Müller, R. (2011). High affinity PPARbeta/delta-specific ligands with pure antagonistic or inverse agonistic properties. Mol. Pharmacol. 80, 828-838.
doi.org/10.1124/mol.111.074039  (free download)

Adhikary, T., Kaddatz, K., Finkernagel, F., Schönbauer, A., Meissner, W., Scharfe, M., Jarek, M., Blöcker, H., Müller-Brüsselbach, S. and Müller, R. (2011). Genomewide analyses define different modes of transcriptional regulation by PPARbeta/delta. PLoS One 6(1): e16344.
doi.org/10.1371/journal.pone.0016344  (free download)

Stockert, J., Adhikary, T., Kaddatz, K., Finkernagel, F., Meissner, W., Müller-Brüsselbach, S. and Müller, R. (2011). Reverse crosstalk of TGFbeta and PPARbeta/delta signaling identified by transcriptional profiling. Nucleic Acids Res. 39, 119-131.
doi.org/10.1093/nar/gkq773  (free download)

Kaddatz, K., Adhikary, T., Finkernagel, F., Meissner, W., Müller-Brüsselbach, S. and Müller, R. (2010). Transcriptional profiling identifies functional interactions of TGFbeta and PPARbeta/delta signaling: synergistic induction of ANGPTL4 transcription. J. Biol. Chem. 285, 29469-29479.
doi.org/10.1074/jbc.M110.142018  (free download)

Naruhn, S., Meissner, W., Adhikary, T., Kaddatz, K., Klein, T., Watzer, B., Müller-Brüsselbach, S. and Müller, R. (2010). 15-Hydroxyeicosatetraenoic acid (15-HETE) is a preferential PPARbeta/delta ligand. Mol. Pharmacol. 77, 171-184.
doi.org/10.1124/mol.109.060541   (free download)


Last modified 21.08.2019