SELECTED PUBLICATIONS
Steitz, A.M., Schröder, C., Knuth, I., Keber, C.U., Sommerfeld, L., Finkernagel, F., Jansen, J.M., Wagner, U., Müller-Brüsselbach, S., Worzfeld, T., Huber, M.,
Beutgen, V.M., Graumann, J., Pogge von Strandmann, E., Müller, R. and Reinartz, S. (2023).
TRAIL-dependent apoptosis of peritoneal mesothelial cells by NK cells promotes ovarian cancer invasion.
iScience 26, 108401.
Ojasalu, K., Lieber, S., Sokol, A.M., Nist, A., Stiewe, T., Bullwinkel, I., Finkernagel, F., Reinartz, S., Müller-Brüsselbach, S., Grosse, R., Graumann. J. and Müller. R. (2023).
The lysophosphatidic acid-regulated signal transduction network in ovarian cancer cells and its role in actomyosin dynamics, cell migration and entosis.
Theranostics 13, 1921-1948.
Sivakumar, S., Lieber, S., Librizzi, D., Keber, C., Sommerfeld, L., Finkernagel, F., Roth, K., Reinartz, S., Bartsch, J.W., Graumann, J., Müller-Brüsselbach, S. and Müller, R. (2023).
Basal cell adhesion molecule (BCAM) promotes metastasis-associated processes in ovarian cancer. Clin. Transl. Med. 13:e1176.
Preußer, C., Stelter, K., Tertel, T., Linder, M., Helmprobst, F., Szymanski, W., Graumann, J., Reinartz, S., Giebel, B., Müller, R., Weber, G. and Pogge von Strandmann, E. (2022).
Isolation of native EVs from primary biofluids – Free-flow electrophoresis as a novel approach to purify ascites-derived EVs.
J. Extracell. Biol., DOI: 10.1002/jex2.71.
Sommerfeld, L., Knuth, I., Finkernagel, F., Pesek, J., Nockher, W.A., Jansen, J.M., Wagner, U., Nist, A., Stiewe, T., Müller-Brüsselbach, S., Müller, R. and Reinartz, S. (2022).
Prostacyclin released by cancer-associated fibroblasts promotes immunosuppressive and pro-metastatic macrophage polarization in the ovarian cancer microenvironment.
Cancers 14, 6154.
Hammoud M.K., Dietze, R., Pesek, J., Finkernagel. F., Unger, A., Bieringer, T., Nist. A., Stiewe, T., Bhagwat, A.M., Nockher, W.A., Reinartz, S., Müller-Brüsselbach, S.,
Graumann, J. and Müller, R. (2022).
Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK-STAT signaling in macrophages by perturbing lipid raft structures.
Mol. Oncol. 16, 3146-3166
Sommerfeld, L., Finkernagel, F., Jansen, J. M., Wagner, U., Nist, A., Stiewe, Müller-Brüsselbach, S., Sokol, A.M., Graumann, J., Reinartz, S. and Müller, R. (2021).
The multicellular signaling network of ovarian cancer metastases.
Clin. Transl. Med. 11, e633.
Dietze, R., Hammoud, M., Gómez-Serrano, M., Unger, A., Bieringer, T., Finkernagel, F., Sokol, A., Nist, A., Stiewe, T., Reinartz, S., Ponath, V., Preußer, C., Pogge von Strandmann, E.,
Müller-Brüsselbach, S., Graumann, J. and Müller, R. (2021).
Phosphoproteomics identify arachidonic-acid-regulated signal transduction pathways modulating macrophage functions with implications for ovarian cancer.
Theranostics 11, 1377-1395.
Ojasalu, K., Brehm, C., Hartung, K., Nischak, M., Finkernagel, F., Rexin, P., Nist, A., Pavlakis, E., Stiewe, T., Jansen, J.M., Wagner, U., Gattenlöhner, S., Bräuninger, S.,
Müller-Brüsselbach, S., Reinartz, S. and Müller, R. (2020).
Upregulation of mesothelial genes in ovarian carcinoma cells is associated with an unfavorable clinical outcome and the promotion of cancer cell adhesion.
Mol. Oncol. 14, 2142–2162.
Steitz, A.M., Steffes, A., Finkernagel, F., Unger, A., Sommerfeld, L., H., Jansen, J.M., Wagner, U., Graumann, J., Müller, R. and Reinartz, S. (2020).
Tumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C.
Cell Death Dis., 11, 249.
Graumann, J., Finkernagel, F., Reinartz, S., Stief, T., Brödje, D., Renz, H., Jansen, J.M., Wagner, U., Worzfeld, T., Pogge von Strandmann, E. and Müller, R. (2019).
Multi-platform affinity proteomics identify proteins linked to metastasis and immune suppression in ovarian cancer plasma.
Front. Oncol. 9:1150.
Finkernagel, F., Reinartz, S., Schuldner, M., Malz, A., Jansen, J.M., Wagner, U., Worzfeld, T., Graumann, J., Pogge von Strandmann, E. and Müller, R. (2019).
Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment.
Theranostics 9, 6601-6617.
Schuldner, M., Dörsam, B., Shatnyeva, O., Reiners, K.S., Kubarenko, A., Hansen, H.P., Finkernagel, F., Roth, K., Theurich, S., Nist, A. Stiewe, T., Paschen, A., Knittel, G., Reinhardt, H.C., Müller, R., Hallek, M. and Pogge von Strandmann, E. (2019).
Exosome-dependent immune surveillance at the metastatic niche requires BAG6 and CBP/p300-dependent acetylation of p53.
Theranostics 9, 6047-6062.
Reinartz, S., Lieber, S., Pesek, J., Brandt, D.T., Asafova, A., Finkernagel, F., Watzer, B., Nockher, W.A., Nist, A., Stiewe, T., Jansen, J.M., Wagner, U., Konzer, A., Graumann, J., Grosse, R., Worzfeld, T., Müller-Brüsselbach, S. and Müller, R. (2019).
Cell-type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment.
Mol. Oncol. 23, 185-201.
Lieber, S., Reinartz, S., Raifer, H., Finkernagel, F., Dreyer, T., Bronger, H., Jansen, J.M., Wagner, U., Worzfeld, T., Müller, R. and Huber, M. (2018).
Prognosis of ovarian cancer is associated with effector memory CD8+ T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells.
Oncoimmunology 17, 270-289.
Worzfeld, T., Finkernagel, F., Reinartz, S., Konzer, K., Adhikary, T., Nist, A., Stiewe, T., Wagner, U., Looso, M., Graumann, J. and Müller, R. (2018).
Proteotranscriptomics reveal signaling networks in the ovarian cancer microenvironment.
Mol. Cell. Proteomics 17, 270-289.
Vyas, M., Reinartz, S., Hoffmann, N., Reiners, K.S., Lieber, S., Jansen, J.M., Wagner, U., Müller, R. and Pogge von Strandmann, E. (2017).
Soluble NKG2D ligands in the ovarian cancer microenvironment are associated with an adverse clinical outcome and decreased memory effector T cells independent of NKG2D down-regulation.
Oncoimmunology 6(9):e1339854.
Adhikary, T., Wortmann, A. , Finkernagel, F., Lieber, S., Nist, A., Stiewe, T., Wagner, U., Müller-Brüsselbach, S. Reinartz, S. and Müller, R. (2017).
Interferon signaling in ascites-associated macrophages is linked to a favorable clinical outcome in a subgroup of ovarian carcinoma patients. BMC Genomics 18: 243.
Pogge von Strandmann, E., Reinartz, S., Wagner, U. and Müller, R. (2017).
Tumor-host cell interactions in ovarian cancer: pathways to therapy failure. Trends Cancer 3, 137-148.
Worzfeld, T., Pogge von Strandmann, E., Huber, M., Adhikary, T., Reinartz, S., Wagner, U. and Müller, R. (2017).
The unique molecular and cellular microenvironment of ovarian cancer. Front. Oncol. 7; doi:10.3389/fonc.2017.00024.
Finkernagel, F., Reinartz, S., Lieber, S., Adhikary, T., Wortmann, A., Hoffman, N., Bieringer, T., Nist, A., Stiewe, T., Jansen, J.M., Wagner, U., Müller-Brüsselbach, S. and Müller, R. (2016).
The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization. Oncotarget. 17, 75339-75352.
Pogge von Strandmann, E. and Müller, R. (2016). Shipping drug resistance: Extracellular vesicles in ovarian cancer. Trends Mol. Med. 22, 741-743.
Reinartz, S., Finkernagel, F., Adhikary, T., Rohnalter, V., Schumann, T., Schober, Y., Nockher, A.W., Nist, A., Stiewe, T., Jansen, J.M., Wagner, U., Müller-Brüsselbach, S. and Müller, R. (2016).
A transcriptome-based global map of signaling pathways in the ovarian cancer microenvironment associated with clinical outcome. Genome Biol. 17: 108.
Rohnalter, V., Roth, K., Finkernagel, F., Adhikary, T., Obert, J., Dorzweiler, K., Bensberg, M., Müller-Brüsselbach, S. and Müller, R. (2015). A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype. Oncotarget 6, 40005-40025.
Schumann, T., Adhikary, T., Wortmann, A., Finkernagel, F., Lieber, S., Schnitzer, E., Legrand, N., Schober, Y, Nockher, A. W., Toth, P.M., Diederich, W.E., Nist, A., Stiewe, T., Wagner, U., Reinartz, S., Müller-Brüsselbach, S. and Müller, R. (2015). Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment. Oncotarget 6, 13416-13433.
Reinartz, S., Schumann, T., Finkernagel, F., Wortmann, A., Jansen, J.M., Meissner, W., Krause, M., Schwörer, A.-M., Wagner, U., Müller-Brüsselbach, S. and Müller, R. (2014). Mixed-polarization phenotype of ascites-associated macrophages in human ovarian carcinoma: correlation of CD163 expression, cytokine levels and early relapse. Int. J. Cancer 134, 32-42.