Applications

We are inviting applications from students of biology, biochemistry, chemistry or bioinformatics and medical students for Ph.D. thesis and M.D. thesis projects in the next round of the Transregio 17 Graduate Program. Also, we invite applications for several postdoctoral positions. Ph.D. thesis projects and postdoctoral positions are funded for an initial period of three years. M.D. thesis projects will be funded for up to one year; MD students are welcome to participate in all projects listed below.

Individual Projects will focus on:
Using genetically defined mouse models to uncover the molecular basis of cancer progression. (PhD Student(s))
Advisor:  Daniel J Murphy, Würzburg

Characterization of mutant p53 knock-in mice with mutations affecting DNA binding cooperativity (Ph.D. student or postdoctoral fellow) 
Advisor: Thorsten Stiewe, Marburg 

Systematic RNAi screens to identify modulators of p53/p73 function (Postdoctoral fellow)
Advisor: Thorsten Stiewe, Marburg

Epigenetic regulation of the p73 tumor suppressor (Ph.D. student or postdoctoral fellow)
Advisor: Thorsten Stiewe, Marburg

Molecular analysis of synthetic lethal interactions with deregulated N-Myc in human neuroblastoma (Ph.D. student)
Advisor: Martin Eilers, Würzburg

Analysis of a novel signaling pathway that controls Myc expression in colorectal carcinogenesis (Ph.D student)
Advisor: Martin Eilers, Würzburg

Genome-wide identification of synthetic lethal interactions with deregulated Myc using high-throughput lentiviral shRNA screens (postdoctoral fellow; for either a molecular biologist or a bioinformatian)
Advisor: Martin Eilers, Würzburg

Project A6: Role of oncogenic NFAT in pancreatic cancer development and progression (1 x 0.5 PhD)
Advisor: Volker Ellenrieder, Marburg

Analysis of Next Generation Resequencing data in hematological malignancies (postdoctoral fellowship in bioinformatics)
Advisor: Andreas Rosenwald, Würzburg

The project C3 has to parts:
In the fist part we intend to find the molecular background for the favourable course of patients with acute myeloid leukemia, whose tumor cells harbour oncogenic RAS, and who had been treated with high-dose cytarabine as consolidation therapy.
In the second part of the C3 project we intend to analyze the molecular background for another clinical observation; the oncogene SKI, which is a transcriptional repressor in many cell types, is highly up-regulated in certain acute myeloid leukemia cells, the molecular background for the SKI induced myeloid transformation however is rather unknown. (2 Ph.D. students, 1 postdoctoral fellow)
Advisors: Andreas Neubauer, Uta-Maria Bauer, Marburg)

Please apply to (preferentially by E-mail):
Martina Janowski
Institut für Molekularbiologie und Tumorforschung
Emil-Mannkopff-Str. 2
35033 Marburg
E-mail: janowski@imt.uni-marburg.de
Phone: 49-6421-28 66768

The deadline for applications is February 28, 2010. Please send transcripts of records and names of up to three references. If applicable, you can list projects and/or advisors that you would prefer to work with.

Posterdownload: Molecular Cancer Biology