<H1>IMT</H1>   Identification of Novel Targets for Cancer Therapy


Agendia

AGENDIA B.V.
Slotervaart Hospital
Floor 9D
Louwesweg 6
NL-1066 EC AMSTERDAM
The Netherlands
Phone: +31 20 512 9161
Fax: +31 20 512 9162
E-Mail: info@agendia.com
Homepage: http://www.agendia.com


Specific aims of the project

Generation of prognostic gene expression signatures in three types of human cancer

Background of the group

Agendia focuses on the development of new prognostic tools, based on gene expression profiling, to be used in oncology. The company has its roots in the Netherlands Cancer Institute / Antoni van Leeuwenhoek hospital (NKI-AVL) in Amsterdam, The Netherlands, an internationally renowned cancer research center. Agendia's first product is MammaPrint®, a gene expression profiling service to assess the risk of recurrence in breast cancer patients. Through MammaPrint® and future products, Agendia wants to enable cancer patients to benefit immediately from the latest scientific findings in cancer research.

References

van 't Veer, L.J., Dai, H., van de Vijver, M.J., He, Y.D., Hart, A. A. M., Mao, M., Peterse, H.L., van der Kooy, K., Marton, M. J., Witteveen, A.T., Schreiber, G. J., Kerkhoven, R. M., Roberts, C., Linsley, P. S., Bernards, R., and Friend, S. H. (2002).
Gene expression profiling predicts clinical outcome of breast cancer.
Nature 415, 530-536.

Van de Vijver, M.J., He, Y.D., van 't Veer, L.J., Dai, H., A M Hart, A.A.M., Voskuil, D., Schreiber, G.J., Peterse, J.L., Roberts, C., Marton, M.J., Parrish, M., Atsma, D., Witteveen, A., Glas, A., Delahaye, L., van der Velde, T., Bartelink, H., Rodenhuis, S., Rutgers,E. Th., Friend, S.H. and Bernards, R.. (2002).
A gene expression signature as a predictor of survival in breast cancer.
New England J. Med. 347, 1999-2009.

Bernards, R. and Weinberg, R.A. (2002).
Metastasis genes: A progression puzzle.
Nature, 418, 823.

Weigelt, B., Glas, A. M., Wessels, L. F., Witteveen, A. T., Peterse, J. L., van't Veer, L. J. (2003).
Gene expression profiles of primary breast tumors maintained in distant metastases.
Proc Natl Acad Sci U S A, 100, 15901-5.

Glas, A.M., Kersten, M.J., Delahaye, L.J.M.J., Witteveen, A.T., Kibbelaar, R.E., Velds, A., Wessels, L.F.A., Joosten, P., Kerkhoven, R.M., Bernards, R., van Krieken, J.H.J.M., Kluin, P.M., van 't Veer, L.J., de Jong, D. (2004).
Gene expression profiling in Follicular Lymphoma to assess clinical aggresiveness and to guide the choice of treatment.
Blood, Epub ahead of print.

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   Agendia
   Michel Aguet
   Manuela Baccarini
   René Bernards
   Anton Berns
   María Blasco
   Anne Dejean
   Martin Eilers
   Kristian Helin
   Marten van Lohuizen
   Clemens Schmitt
   Manuel Serrano
   Andreas Trumpp
   Karen Vousden
   Lutz Weber
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