We study how transcription is regulated in disease as well as its modulation by druggable factors, in particular by nuclear receptors.
We are investigating the epigenetic and gene-regulatory functions of protein arginine methyltransferases (PRMTs) in mammalian cells.
We maintain a large scale fly culture and are combining biochemical, genetic and molecular biology approaches to investigate conserved tumour suppressor complexes and chromatin regulators.
We are looking into the functional role of tumor-cell secreted Hedgehog ligands on the tumor cells themselves and on their surrounding normal stromal cells.
We aim to better understand the regulatory mechanisms of the polycomb repressive complex 2 (PRC2) in a physiological and pathophysiological context. In particular we want to better understand the role of PRC2-associated factors in stem cell biology and cancer.
We wish to understand the chromatin-based mechanisms which control the identity and fate of mammalian cells.
Our main research interest is translational cancer research with a focus on human ovarian cancer. We are particularly interested in transcriptional networks, therapy resistance, the tumor microenvironment and tumor metabolism. This work is closely linked to our interest in the nuclear receptor PPARβ/δ.
Our general research interest is mammalian gene regulation. In particular, we are focusing on the biological and molecular functions exerted by members of the Sp family of transcription factors.